Nino Caffe began his artistic training under the guidance of the painter Spagnolini and, once moved in Pesaro in 1930, was a part of the lively cultural and artistic life of the city, familiar with many local artists. In 1935 he graduated from the Art Institute of Urbino where he later taught in 1943 and 1944. He moved to Rome and opened a studio gallery leaning on the Obelisk. Caffe held numerous solo exhibitions like the Galleria Gianferrari of Milan (1944) and the Gallery of the birthplace of Rossini (1946). He also participated in 1938 at the Venice Biennale.